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The future of healthy aging

Science-backed tools designed to improve your healthspan and longevity.

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  • Defend
  • Defend
  • Defend
  • Defend
  • Defend
  • Defend

Staff Pick

  • 60 Capsules
  • 30-Day Supply
4.8
| 3,379+ ORDERS
Third-party safety certified

Defend Against Inflammaging

Built for Immune Resilience, Not Just Cold Season

  • BEST VALUE $74.00 $62.90
  • $74.00

Defend is designed to promote a healthy, vibrant immune system while simultaneously targeting immune-related aging hallmarks.

  • Targets inflammaging, not just symptoms
  • Primes your immune system to respond faster
  • Supports resilience year-round

Free shipping • Pause or cancel any time

HSA/FSA eligible via TruMed

Defend

Inflammaging Support

$51.80 $74.00

  • Vegan
  • Non-GMO
  • Gluten free
  • 9 major allergen free
  • Endotoxin-free
  • No preservatives

Immunity + Longevity Formulation

In One Dose of Defend

Clean ingredients, no filler. Each one dosed at levels studied in human research and chosen to address hallmarks of aging.

  • Beta-glucan

    Beta-glucan

    Beta-glucan primes immune cells to recognize and respond to threats more effectively

    30mg

  • Quercetin

    Quercetin

    Quercetin is a flavonoid studied for lowering inflammation and supporting healthy immune cell activity

    500mg

  • Vitamin C

    Vitamin C

    Vitamin C fuels white blood cell function, helping your body mount a faster immune response

    90mg

  • Zinc

    Zinc

    Zinc supports immune cell development and helps keep inflammatory response in check

    11mg

  • Vitamin D3

    Vitamin D3

    Vitamin D3 supports immune signaling and helps maintain balanced, healthy immune function

    1000IU

Manufactured in the USA with global ingredients

Why Tally Health

Built to address the biology of aging.

Every ingredient has to clear three bars before it made it into our signature formula. If an ingredient doesn't meet all three, it doesn't go in the capsule.

  • Proven Safe

    Proven safe and well-tolerated in double-blind placebo-controlled human trials

  • Targets Root Causes

    Strong mechanistic evidence it addresses a hallmark of aging

  • Backed by Real Data

    Published lifespan and healthspan data in animal models

  • Altered intercellular communication
  • Cellular senescence
  • Chronic inflammation
  • Deregulated nutrient-sensing
  • Disabled macroautophagy
  • Dysbiosis
  • Epigenetic alterations
  • Genomic instability
  • Loss of proteostasis
  • Mitochondrial dysfunction
  • Stem cell exhaustion
  • Telomere attrition

Changes You Can Feel

Discover how Defend helps enhance your health overnight and over time.

  • 1 week

    Initial targeting of immune-related aging hallmarks and pathways

  • 4 weeks

    Vitamin D3 levels are expected to rise compared to baseline

  • 3 months

    May notice an increase in overall immune resilience

  • 6 months

    Expected improvements in cellular health, including less cellular senescence and inflammaging

Within 12 months, over 62% of Tally Health members lowered their epigenetic age by an average of 2+ years

Verified 5 Star Reviews

Our community loves Defend

  • "A great set of scientifically backed ingredients. Helps me stay healthy during the winter."
    Max S. Tally Subscriber
  • "I travel a lot for work, and am prone to getting sick following long days and intensive travel... I just started taking Defend and am excited to strengthen my immune system."
    Brian B. Tally Subscriber

Powerful solo. Unbeatable combined.

Our scientist-formulated supplements are expertly stacked with synergistic ingredients to help accelerate your health goals.