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The future of healthy aging

Science-backed tools designed to improve your healthspan and longevity.

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  • Sharpen
  • Sharpen
  • Sharpen

Brain Health

Sharpen

$69.00

Sharpen is designed to unlock better memory, clearer thinking, and improved focus as you age.

  • Encourages long-term cognitive wellness
  • Maintains brain health as you age
  • Provides memory support
  • Promotes aspects of focus and performance

The five key ingredients in Sharpen are Taurine (1000mg), Choline (200mg), Vitamin B6 (1.7mg), L-methylfolate (400mcg DFE), and Vitamin B12 (2.4mcg)

Take two capsules daily, with food. Consider starting with one capsule per day and progressively increasing your dose. For best results, take for a minimum for six months and beyond. Each 30-day supply includes 60 capsules.

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Sharpen

$69.00

  • Vegan
  • Non-GMO
  • Gluten free
  • 9 major allergen free
  • Endotoxin-free
  • No Preservatives

Optimize brain health at a cellular level

Sharpen is designed to:

  • Support long-term cognitive health and overall performance

    By providing evidence-based ingredients that help strengthen multiple aspects of cognition, including memory 1,2,3,4,5

    • Bae et al. Advances in Experimental Medicine and Biology 2019.
    • Knott et al. Pharmacology Biochemistry and Behavior 2015.
    • Deijen et al. Psychopharmacology 1992.
    • Stahl. The Journal of Clinical Psychiatry 2008.
    • Ueno et al. Nutrients 2022.

  • Lower a risk factor for dementia by decreasing homocysteine levels

    Homocysteine levels reflect the activity of vitamins B6, B9 (folate), and B12 6

    • Smith et al. Journal of Alzheimer's Disease 2018.

  • Provide a precursor to the neurotransmitter acetylcholine

    Acetylcholine plays critical roles in learning and memory 7

    • Wurtman and Melamed. Pharmacological Reviews 1980.

  • Promote aspects of focus and performance

    By supporting the nervous system and neuronal communication 8

    • Naber et al. Scientific Reports 2015.

Trusted ingredients

Our pursuit for living healthier, longer is only matched by our relentless pursuit for quality. If an ingredient doesn’t meet our standards, we don’t use it.

  • Formulated by scientists

  • Ingredients backed by peer-reviewed research

  • Premium-quality, lab-tested ingredients

  • Third-party safety certified

Research-backed ingredients

Our formulas are made with a powerful combination of ingredients that have been shown in research studies to promote longevity and improve healthspan.

  • Taurine

    1000mg

    Benefits:

    • Supports overall brain health 9
    • Improves lifespan and healthspan in mammals 10
    • Boosts cognitive function and performance 1
    • Stimulates new brain cell formation 11

  • Choline

    200mg

    Benefits:

    • Enhances working and verbal memory 2
    • Promotes focus and cognitive performance 8
    • Linked to an improvement in brain fog 12
    • Precursor to the neurotransmitter acetylcholine 7

  • Vitamin B6

    1.7mg

    Benefits:

    • Boosts memory in healthy elderly adults 3
    • Lowers a risk factor for dementia
      by decreasing homocysteine levels 6
    • Promotes a healthy nervous system 13
    • Supports synthesis of key neurotransmitters 14

  • L-Methylfolate

    400 mcg DFE

    Benefits:

    • Decreases oxidative stress 15
    • Relates to superior cognitive test scores 16
    • Lowers a risk factor for dementia
      by decreasing homocysteine levels 17
    • Active, brain-permeable form of folate 4

  • Vitamin B12

    2.4 mcg

    Benefits:

    • Strengthens cognition 5
    • Lowers a risk factor for dementia
      by decreasing homocysteine levels 18
    • Neuroprotective for the nervous system 19
    • Supports brain oxygenation 20

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Scientific References

  1. Bae et al. The Development of Taurine Supplementary Menus for the Prevention of Dementia and Their Positive Effect on the Cognitive Function in the Elderly with Dementia. Advances in Experimental Medicine and Biology 2019
  2. Knott et al. Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers. Pharmacology Biochemistry and Behavior 2015
  3. Deijen et al. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology 1992
  4. Stahl. L-methylfolate: a vitamin for your monoamines. The Journal of Clinical Psychiatry 2008
  5. Ueno et al. Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment. Nutrients 2022
  6. Smith et al. Homocysteine and Dementia: An International Consensus Statement. Journal of Alzheimer's Disease 2018
  7. Wurtman and Melamed. Precursor control of neurotransmitter synthesis. Pharmacological Reviews 1980
  8. Naber et al. Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study. Scientific Reports 2015
  9. Chen et al. Roles of taurine in cognitive function of physiology, pathologies and toxication. Life Sciences 2019
  10. Singh et al. Taurine deficiency as a driver of aging. Science 2023
  11. Gebara et al. Taurine increases hippocampal neurogenesis in aging mice. Stem Cell Research 2015
  12. Monastero and Baschi. Persistent Cognitive Dysfunction in a Non-Hospitalized COVID-19 Long-Hauler Patient Responding to Cognitive Rehabilitation and Citicoline Treatment. Brain Sciences 2023
  13. CalderĂłn-Ospina and Orlando Nava-Mesa. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neuroscience & Therapeutics 2020
  14. Parra et al. Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells 2018
  15. Cagnacci et al. Folate administration decreases oxidative status and blood pressure in postmenopausal women. European Journal of Nutrition 2015
  16. Morris et al. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. The American Journal of Clinical Nutrition 2010
  17. Sicińska et al. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. International Journal of Food Sciences and Nutrition 2018
  18. Lee et al. Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials. Aging (Albany NY) 2024
  19. Didangelos et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2021
  20. Green. Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood 2017