NAD+ Dosage Per Day: What the Science Says

Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme involved in cellular energy production , DNA repair , and metabolic regulation . NAD+ is involved in various cellular processes and biological processes, including energy production, DNA repair, and immune system function. NAD+ levels often decline with age, which may contribute to reduced mitochondrial function and age-related health conditions [1,2]. This decline is associated with cellular aging, cognitive problems, and metabolic disorders.

Supplementation with NAD+ precursors—such as niacinamide (NAM) , nicotinamide riboside (NR) , or nicotinamide mononucleotide (NMN) —has gained popularity for its potential to restore NAD+ levels and support healthy aging [3]. After mentioning mitochondrial function, it is important to highlight the importance of mitochondrial health and cellular homeostasis, and that maintaining cellular homeostasis is crucial for healthy aging. NAD+ supplementation has potential health benefits that extend beyond energy production, including promoting cellular health, supporting brain health, supporting neuronal health, and improving cognitive function and mental clarity. NAD+ is essential for cellular function, cellular health, and energy metabolism, and its utility extends to muscle function, physical performance, and body composition. NAD+ also plays a role in immune system function by supporting immune cells and cellular stress resistance, as underlying inflammatory conditions and chronic inflammation can increase NAD+ consumption. Chronic stress, environmental toxins, excessive alcohol consumption, and alcohol consumption can deplete NAD+ levels, and lifestyle factors and healthy lifestyle choices, such as a healthy diet rich in essential nutrients and regular physical activity, are important for maintaining NAD+ levels and supporting the body's natural processes.

Randomized controlled trials are ongoing to better understand the anti-aging benefits of NAD+ and its role in combatting age-related decline. NAD+ supports DNA repair mechanisms and is a key focus of research for promoting human health and overall health.

There’s no official “NAD+ RDA,” but multiple human studies [4-8] offer guidance on effective dosage ranges for NAD+ precursors. The appropriate NAD+ dosage may depend on individual health status and should be discussed with a qualified healthcare professional or healthcare provider.

Most studies on NAD supplementation report few adverse effects, but it is important to consult healthcare providers or qualified healthcare professionals before starting NAD+ precursor supplementation to ensure safety and proper dosing. Current dosage recommendations are based on available clinical evidence, and more large-scale randomized controlled trials are needed to establish optimal dosing and long-term safety.

At 1,000 mg per day, Tally Health’s NAD+ supplement delivers a science-backed dose of niacinamide—without the flushing associated with high-dose niacin or the regulatory gray zone associated with NMN.

Recent studies show that:

• Longer-term niacinamide use has been reported to be safe at doses under 3,000 mg/day [8].

• Niacinamide avoids the “niacin flush” side effect common with nicotinic acid supplements.

• NAM is well-recognized as an NAD+ precursor that can boost NAD+ levels via the salvage pathway. Specifically, NAM is converted into NMN, which is then converted into NAD+.

Most studies on NAD supplementation report minimal adverse effects at recommended doses, but individuals should be aware of potential adverse effects when taking NAD supplements and consult a healthcare professional before starting.

Furthermore, niacinamide is a well-characterized, FDA-recognized nutrient with a long track record of safe use in both supplements and food fortification. NAD+ supplementation is generally considered safe when following recommended guidelines.

While NMN is a popular NAD+ precursor, it was removed from the U.S. supplement market after the FDA determined it had previously been investigated as a pharmaceutical drug. As a result, NMN can no longer be sold as a dietary supplement in the U.S. unless further approvals are granted.

By contrast, Niacinamide remains fully compliant with U.S. FDA supplement regulations and is recognized as Generally Recognized as Safe (GRAS) for oral intake.