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Vitality Supplement: What It Is, How It Works, and Why Tally Health’s Formula Stands Out

Published:

TL;DR

  • Vitality supplements are designed to support cellular energy, mitochondrial function, and resilience against age-related decline.

  • Tally Health’s Vitality formula provides a complete blend of essential nutrients and bioactives to support your body's needs.

  • Tally Health’s Vitality formula combines five scientifically backed ingredients: Calcium alpha-ketoglutarate, quercetin, trans-resveratrol, fisetin, and spermidine. Each compound targets distinct hallmarks of aging , including inflammaging, cellular senescence, mitochondrial efficiency, and autophagy. It is designed to boost energy and optimize cellular function, helping you feel your best.

  • Together, these ingredients create a synergistic formula that supports longevity pathways and promotes youthful energy and cellular resilience.

What is a Longevity Supplement?

A close-up, soft-focus shot of several supplement capsules. The text on the left reads: "Longevity Supplements. A blend of nutrients, antioxidants, vitamins and minerals intended to support healthy aging at the cellular level." The capsules appear to be two different colors, a dark burgundy and a yellowish color.
Image from Tally Health

A longevity supplement is often a blend of nutrients, antioxidants, vitamins and minerals, and plant-derived bioactives intended to support energy, performance, and healthy aging at the cellular level. These supplements help meet the nutritional needs of your body by providing essential vitamins, minerals, and bioactives.


Unlike conventional multivitamins, these formulas often draw on the latest research to target fundamental drivers of aging: chronic inflammation, mitochondrial dysfunction, cellular senescence, and deregulated nutrient sensing [1–3]. Longevity supplements offer a science-backed way to support your body's natural energy and resilience through optimal nutrition.

What Makes Tally Health’s Vitality Formulation Unique?

A graphic showing a dark burgundy supplement capsule labeled "VITALITY." To the right, a list of five ingredients is displayed: "CA-AKG," "Quercetin," "Trans-resveratrol," "Fisetin," and "Spermidine." The heading reads "5 science-backed longevity ingredients in one formulation."
Image from Tally Health

Tally Health’s  Vitality supplement is made with high-quality ingredients and produced to the highest standards. It is one of the best options on the market for supporting overall wellness and helping you feel well. Formulated with five key ingredients that are backed by preclinical and human evidence in the field of aging science, each compound plays a unique role:

1. Calcium Alpha-Ketoglutarate (1,000 mg)

  • A core TCA cycle intermediate, Alpha-Ketoglutarate (AKG) is critical for energy metabolism and epigenetic regulation, working alongside other essential minerals to support energy production and metabolism.

  • In animal models, AKG extends lifespan and healthspan, partly by reducing systemic inflammation and maintaining stem cell function [4,5].

  • In humans, AKG has been largely historically studied in the context of exercise performance.

2. Quercetin (500 mg)

  • A natural flavonoid found in apples, onions, and capers, quercetin has potent antioxidant and senolytic properties.

  • Quercetin helps clear senescent (zombie) cells when used in combination with other molecules [6], supporting tissue rejuvenation.

  • It also supports vascular health, mitochondrial function, and immune resilience [7].

3. Trans-Resveratrol (500 mg)

    • Found in grapes and red wine, trans-resveratrol activates sirtuins —key proteins involved in DNA repair, stress resistance, and metabolic regulation [8].

    • It mimics caloric restriction’s effects, improving mitochondrial biogenesis and cellular resilience, and helps maintain healthy energy and nutrient levels in the body [9].

  • Some studies show benefits for insulin sensitivity, cognition, and cardiovascular function [10].

4. Fisetin (100 mg)

  • A lesser-known but powerful plant polyphenol , fisetin acts as a natural senolytic , helping remove dysfunctional cells that accumulate with age [11,12].

  • Fisetin has been shown to extend lifespan in mice , reduce age-related inflammation, and support cognitive function [13]. It helps address problems associated with aging, such as inflammation and cognitive decline.

  • It’s currently under investigation in clinical trials for aging-related conditions.

5. Spermidine (900 mcg)

  • A naturally occurring polyamine that promotes autophagy, supporting a complete cellular cleanup process by which cells clear out damaged components.

  • Spermidine has been linked to lifespan extension in multiple model organisms, and epidemiological studies associate higher intake with reduced mortality risk in humans [14,15].

  • It supports cellular renewal, cognitive function, and heart health [16].

Why These Ingredients Matter for Healthy Aging

Each of the five ingredients in Tally Health’s Vitality supplement targets distinct hallmarks of aging:

A table detailing the ingredients, benefits, and targeted aging hallmarks for the Tally Health supplement. The rows are for Alpha-Ketoglutarate, Quercetin, Trans-Resveratrol, Fisetin, and Spermidine. Each row lists specific benefits (e.g., "Energy metabolism, epigenetic balance") and aging hallmarks (e.g., "Epigenetic alterations, deregulated nutrient-sensing")
Image from Tally Health

How to Take a Vitality Supplement

A graphic explaining the suggested use of the Vitality supplement. Text reads: "Suggested Use. Daily dose of Vitality = 4 capsules. Take with food containing healthy fat (e.g. nuts, seeds, avocados, or a small amount of extra-virgin olive oil). The capsule can be swallowed whole or broken open and mixed into your food. For best results, take for a minimum for six months and beyond." To the right, there are two circular images: one shows a capsule broken open with white powder spilling out, and the other shows a sliced avocado.
Image from Tally Health

Tally Health’s Vitality supplement is designed for daily use , delivering full doses of each ingredient in convenient capsules. You can easily order the supplement online, enjoy free shipping, and have the flexibility to cancel your subscription at any time.It’s best taken with food to support absorption of the fat-soluble polyphenols (e.g., resveratrol).

Is There Human Data on Vitality Supplement Ingredients?

All of the ingredients in Vitality have been studied in placebo-controlled human clinical trials and, indeed, these trials were used to determine the dose of each component. Together, these compounds form a synergistic matrix that addresses multiple aging mechanisms simultaneously.

Final Word: The Future of Vitality Starts Now

A split image. On the left is the Tally Health Vitality supplement bottle with a single capsule in front of it. On the right, a black-and-white image of a single capsule is shown with lines pointing to different parts of the capsule, labeling the ingredients inside: "Calcium alpha-ketoglutarate," "Fisetin," "Quercetin," "Resveratrol," and "Spermidine."
Image from Tally Health

Longevity supplements are no longer about vague energy boosts. They are grounded in cellular biology, science, and longevity research.


Tally Health’s  Vitality supplement is at the forefront of this movement—combining precision doses of five ingredients that work at the cellular level to support a healthier, longer life. It is designed to help bring back your vitality and energy as you age, supporting your overall well-being

What makes Tally Health’s Vitality formulation unique?

Tally Health’s Vitality supplement is made with high-quality ingredients and produced to the highest standards. It includes five key compounds—Alpha-Ketoglutarate, Quercetin, Trans-Resveratrol, Fisetin, and Spermidine—each backed by preclinical and human data and selected for their ability to target specific hallmarks of aging and support energy, cognition, and cellular resilience.

Is there human data on Vitality supplement ingredients?

Yes. All of the ingredients in Vitality have been studied in placebo-controlled human clinical trials, and these trials were used to determine the dosage of each component. Together, the compounds form a synergistic matrix that addresses multiple aging mechanisms simultaneously.

What is a longevity supplement?

A longevity supplement is often a blend of nutrients, antioxidants, vitamins and minerals, and plant-derived bioactives intended to support energy, performance, and healthy aging at the cellular level. Unlike conventional multivitamins, these formulas often draw on the latest research to target fundamental drivers of aging such as chronic inflammation, mitochondrial dysfunction, cellular senescence, and deregulated nutrient sensing.

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Citations

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  2. Kennedy BK, Berger SL, Brunet A, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159(4):709–713. doi:10.1016/j.cell.2014.10.039. PMID: 25417146.

  3. Campisi J, Kapahi P, Lithgow GJ, et al. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571(7764):183–192. doi:10.1038/s41586-019-1365-2. PMID: 31292559.

  4. Asadi Shahmirzadi A, Edgar D, Liao C-Y, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metab. 2020;32(3):447–456.e6. doi:10.1016/j.cmet.2020.07.016. PMID: 32814060.

  5. Chin RM, Fu X, Pai MY, et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510(7505):397–401. doi:10.1038/nature13264. PMID: 24828042.

  6. Zhu Y, Tchkonia T, Pirtskhalava T, et al. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015;14(4):644–658. doi:10.1111/acel.12344. PMID: 25870184.

  7. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2-3):325–337. doi:10.1016/j.ejphar.2008.03.008. PMID: 18417120.

  8. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493–506. doi:10.1038/nrd2060. PMID: 16732220.

  9. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell. 2006;127(6):1109–1122. doi:10.1016/j.cell.2006.11.013. PMID: 17112576.

  10. Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612–622. doi:10.1016/j.cmet.2011.10.002. PMID: 22055504.

  11. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18–28. doi:10.1016/j.ebiom.2018.09.015. PMID: 30279114.

  12. Zhu Y, Doornebal EJ, Pirtskhalava T, et al. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors A1331852 and A1155463. Aging (Albany NY). 2017;9(3):955–963. doi:10.18632/aging.101202. PMID: 28273655.

  13. Youssefzadeh MJ, et al. Senolytic effects of fisetin in aged mice. Aging Cell. 2018. PMID: 30450772.

  14. Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009;11(11):1305–1314. doi:10.1038/ncb1975. PMID: 19801973.

  15. Kiechl S, Pechlaner R, Willeit P, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Am J Clin Nutr. 2018;108(2):371–380. doi:10.1093/ajcn/nqy102. PMID: 30052863.

  16. Schwarz C, Horn M, Dragano N, et al. Spermidine intake is associated with cognitive performance in older adults. Cell Reports. 2021;35(5):109072. doi:10.1016/j.celrep.2021.109072. PMID: 33984266.